https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The role of comorbidities and inflammation in COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27878 Wed 11 Apr 2018 10:26:27 AEST ]]> Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32621 -6) and followed by variants in GAPVD1 (GTPase activating protein and VPS9 domains 1; combined P-value 5.83 × 10-5) and near ZNF697 (combined P-value 8.15 × 10-5).]]> Tue 26 Jun 2018 14:58:14 AEST ]]> The microbiome and host mucosal interactions in urinary tract diseases https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43896 Tue 05 Sep 2023 14:45:12 AEST ]]> Treatable traits for long COVID https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53499 Thu 30 Nov 2023 15:57:52 AEDT ]]> Attack, flare-up, or exacerbation?: The terminology preferences of patients with severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46415 Thu 24 Nov 2022 13:56:58 AEDT ]]> Childhood Hearing Australasian Medical Professionals network: consensus guidelines on investigation and clinical management of childhood hearing loss https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38796 Thu 03 Feb 2022 12:42:36 AEDT ]]> Chronic disease management: seizing the moment in medical education https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5505 Sat 24 Mar 2018 07:47:02 AEDT ]]> Effects of pond salinization on survival rate of amphibian hosts infected with the chytrid fungus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26888 B. dendrobatidis infection, and survival were monitored at 1, 4, and 12 months. The effect of salt on the abundance of nontarget organisms was also investigated in before and after style analyses. Salinities remained constant over time with little intervention. Hosts in water bodies with 4 ppt salt had a significantly lower prevalence of chytrid infection and higher survival, following metamorphosis, than hosts in 0 ppt salt. Tadpoles in the 4 ppt group were smaller in length after 1 month in the release site than those in the 0 and 2 ppt groups, but after metamorphosis body size in all water bodies was similar . In water bodies with 4 ppt salt, the abundance of dwarf tree frogs (Litoria fallax), dragonfly larvae, and damselfly larvae was lower than in water bodies with 0 and 2 ppt salt, which could have knock-on effects for community structure. Based on our results, salt may be an effective field-based B. dendrobatidis mitigation tool for lentic amphibians that could contribute to the conservation of numerous susceptible species. However, as in all conservation efforts, these benefits need to be weighed against negative effects on both target and nontarget organisms.]]> Sat 24 Mar 2018 07:41:41 AEDT ]]> Comorbidity in chronic obstructive pulmonary disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28982 Sat 24 Mar 2018 07:29:26 AEDT ]]> Evidence of a salt refuge: chytrid infection loads are suppressed in hosts exposed to salt https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26986 Batrachochytrium dendrobatidis, temperature and humidity refuge areas for amphibian hosts exist but are difficult to manipulate. Other environmental features that may affect the outcome of infection include water quality, drying regimes, abundance of alternate hosts and isolation from other hosts. We identified relationships between water bodies with these features and infection levels in the free-living hosts inhabiting them. Where significant relationships were identified, we used a series of controlled experiments to test for causation. Infection loads were negatively correlated with the salt concentration of the aquatic habitat and the degree of water level fluctuation and positively correlated with fish abundance. However, only the relationship with salt was confirmed experimentally. Free-living hosts inhabiting water bodies with mean salinities of up to 3.5 ppt had lower infection loads than those exposed to less salt. The experiment confirmed that exposure to sodium chloride concentrations >2 ppt significantly reduced host infection loads compared to no exposure (0 ppt). These results suggest that the exposure of amphibians to salt concentrations found naturally in lentic habitats may be responsible for the persistence of some susceptible species in the presence of B. dendrobatidis. By manipulating the salinity of water bodies, it may be possible to create refuges for declining amphibians, thus allowing them to be reintroduced to their former ranges.]]> Sat 24 Mar 2018 07:25:50 AEDT ]]> Special issue on health and fatherhood https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32314 Mon 23 Sep 2019 12:52:02 AEST ]]> Multidisciplinary analysis of invasive meningococcal disease as a framework for continuous quality and safety improvement in regional Australia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47571 Mon 23 Jan 2023 13:46:24 AEDT ]]> Gastrointestinal Symptoms in Diabetes: Prevalence, Assessment, Pathogenesis, and Management https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47552 Mon 23 Jan 2023 12:29:50 AEDT ]]> Appropriate use of oral corticosteroids for severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43398 Mon 04 Sep 2023 13:18:03 AEST ]]> Assessing host response to disease treatment: how chytrid-susceptible frogs react to increased water salinity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32085 Batrachochytrium dendrobatidis (Bd) is correlated with several environmental variables, including salinity, temperature, and moisture content, which influence the pathogen’s growth and survival. Habitats that contain these environmental variables at levels outside of those optimal for Bd growth and survival may facilitate the survival of susceptible host species. Therefore, manipulation of environmental salinity is a potential management strategy to help conserve Bd-susceptible species. However, host behaviour also influences disease dynamics, and the success of habitat manipulation programs depends on how hosts use this altered habitat. Aims: To assess if the Bd-susceptible green and golden bell frog, Litoria aurea, will select waterbodies with a salinity increased to S = 3; if this selection is affected by infection; and if a frog’s time in a waterbody of this salinity affects infection load or blood physiology. Methods: We conducted a filmed choice experiment and a 3-year field study where infected and uninfected frogs could choose between fresh or saline waterbodies. Key results: In both the laboratory experiment and field study, Bd-infected L. aurea spent a significantly greater amount of time in or closer to a waterbody than uninfected frogs. Experimentally infected frogs tended to prefer the saline water over fresh, but their choice of water usage did not differ statistically from uninfected frogs. In the field, frogs began to avoid ponds when salinities rose above S = 5. Conclusions: Because both wild and captive, and infected and uninfected L. aurea readily selected waterbodies with a salinity of S = 3, this salinity could potentially be used as a passive method for reducing the severity of Bd when managing this species. However, further testing is needed to understand the efficacy of this treatment, and care must be taken to prevent salinities rising above S = 5, because this level seems to produce an avoidance response and therefore may not be suitable in every location. Implications: Manipulation of aquatic habitats may be a worthwhile focus for Bd management in habitats where water level fluctuations are minimal.]]> Fri 27 Apr 2018 14:12:51 AEST ]]> A GP primer for understanding upper gastrointestinal tract biopsy reports https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24284 Fri 18 Nov 2016 10:49:49 AEDT ]]> Effect of a multidisciplinary team approach on the management of diabetic foot ulcers on the Central Coast: A review of the Gosford Hospital High-Risk Foot Clinic https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54666 Fri 08 Mar 2024 10:57:17 AEDT ]]>